Immaculate Conception

Immaculate Conception is an unlockable passive item added in Afterbirth.

Effect

 * Upon picking up enough heart pickups, Isaac gains a permanent angelic familiar. Possible familiars include:
 * Holy Water
 * Guardian Angel
 * Sworn Protector
 * The Relic
 * Seraphim
 * The first and second familiars will spawn after picking up 15 heart pickups each. The third, fourth, and fifth familiars will spawn after picking up 30 heart pickups each. No further familiars will spawn.

Trivia

 * Immaculate Conception refers to the Catholic teaching that the conception of the Virgin Mary was free from original sin.