Plan C

Plan C is an activated item added in Afterbirth †.

Effect

 * Upon use, instantly kills every enemy in the room, then kills Isaac 3 seconds later.

Synergies

 * Extra life items (Dead Cat, 1up!, etc.): Allows Isaac to continue after using Plan C.
 * Lazarus' Rags: Allows Isaac to continue after using Plan C. Unlike other extra life items, Isaac respawns in the same room (as Lazarus Risen).

Trivia

 * This is a reference to the "Morning After" pill that prevents a pregnancy, commonly referred to as "Plan B". It's also a reference to a "cyanide pill" that is fatally poisonous, and can be deliberately taken to commit suicide. It's likely that the item is called "Plan C" because it is too late for a "Plan B" to prevent Isaac from being born; so the "next best thing", Plan C, is for Isaac to kill himself.
 * This item is found in more item pools than any other item in the game.

Plan C