The D6

The D6 is a Special unlockable activated item.

Effect

 * Upon use, replaces every item in the current room (not pickups or trinkets) with other random items corresponding to the current room's item pool.

Trivia

 * Despite the fact that the D6 is considered a Special Item, it will only count as a special item if found naturally during gameplay. Starting with the D6 as Isaac will not cause fewer special items to appear later on. This fact also extends to Eden's starting items: if Eden starts with a special item, that item will not count toward the special item total.
 * In the original Binding of Isaac, the D6 had a recharge time of 3 instead of 6.

Seeds
1FCT ACVE (Treasure Room adjacent to spawn) MD88 E2T6 (Treasure Room below spawn point) RW3X Z3GE (First Treasure Room) ARWQ FG3K (Treasure Room) QCB3 YFVE (First Treasure Room) KG9X ZKAP (Treasure Room in Caves I) Y92T DPY4 (Treasure Room adjacent to spawn) MQSL 4G4L (First Treasure Room) GVYV XHMJ (Treasure Room adjacent to spawn)