D4

The D4 is an unlockable activated item.

Effect

 * Upon use, re-rolls each of Isaac's items into a random item from the Treasure Room item pool.

Bugs

 * Previously held passive items are not removed, just disabled. As such, using the D4 too often will exhaust every single passive item in the Treasure Room item pool, causing items rerolled by D4 to become Breakfast. Treasure Rooms themselves may still contain active items, however.
 * Previously held items are not removed from the pause menu, which makes it difficult to determine which items Isaac currently has.
 * This bug was fixed in Afterbirth.
 * When D4 is used with a co-op baby present, the baby's sprite will turn into a glitched sprite of Isaac.
 * When the D4 has rerolled through all items it will eventually remove all of them upon use.

Seeds
N64W DZPF (Treasure room adjacent to spawn) (Normal mode only) F4BR 0P86 (Treasure room adjacent to spawn) (Hard mode only) 89EX S9KG (Treasure room south of spawn) 7VC9 TRMS (Treasure room adjacent to spawn)

D4