Placebo

Placebo is an activated item added in Afterbirth.

Effect

 * Mimics the effect of Isaac's held pill, like Blank Card does with cards or runes.
 * Does not consume Isaac's held pill.
 * Will not mimic cards or runes.

Synergies

 * 48 Hour Energy: Can be used to generate infinite batteries.
 * Balls Of Steel: Grants 2 soul hearts (like the Blank Card + The Hierophant synergy, except it adds them to your life rather than spawning them).
 * Balls Of Steel + Sharp Plug: The player can gain functional invincibility.
 * Little Baggy: Allows Isaac to hold one more pill than usual, giving the player a choice between two pill effects to copy.
 * Mom's Bottle of Pills: Allows Isaac to access different pills more quickly, but is only useful for the floor on which both items have been found.
 * Virgo, PHD: Pills will only have positive or neutral effects on Isaac.
 * Power Pill: Works as a 4-room recharge version of The Gamekid.
 * Explosive Diarrhea: Spawns five bombs, making it useful for attacking or opening Secret Rooms.
 * Friends Till The End!: Spawns 3 blue flies, similar to Guppy's Head.
 * Hematemesis: Isaac will be set to one red heart and spawn 1-4 Red Heart pickups, which can be useful for Dark Bum if the player has no red hearts.
 * Stat-increasing pills:
 * Range up: Increases range by 2.5 each use. With enough range, tears are fired high enough to travel over obstacles.
 * Luck up: Increases luck by 1. With enough luck, this makes tear effects like Loki's Horns or Mom's Contacts certain or very likely to happen.
 * This can actually have a negative effect on the game's randomness, as some Luck-based events are bugged, so an extremely high Luck stat renders them impossible to activate.
 * One Makes You Smaller pill: Can be used to shrink repeatedly, making dodging enemies and hazards easier.
 * I'm Drowsy...: Can be used repeatedly for instant Stop Watch effect without having to incur damage. This is very useful when fighting Hush and Delirium (especially as The Lost).
 * Gulp!: Can be used as a 4-charge Smelter.

Interactions

 * Starter Deck: All pills are replaced by cards, rendering Placebo useless.
 * One Makes You Larger pill: Can be used to grow repeatedly, making dodging enemies and hazards more difficult.