Cards and Runes

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Pickups
Hearts Coins Bombs Keys Batteries Pills Cards Chests File:DLC Indicator.png Sacks

Cards and runes are usable items with a wide variety of effects. They take up the same slot as pills.

Runes and special cards are unlocked by completing challenges.

Cards[edit | edit source]

Major Arcana Cards[edit | edit source]

When on the ground, these cards look like this: TarotCard.png

Name ID Icon Message Effect
0 - The Fool1 Pickup 0 - The Fool icon.png"Where journey begins"Teleports you back to the starting room of a floor.
I - The Magician2 Pickup I - The Magician icon.png"May you never miss your goal"Grants homing tears for the current room.
II - The High Priestess3 Pickup II - The High Priestess icon.png"Mother is watching you"Mom's dismembered leg is called down to deal 300 damage to anything it stomps. It will always stomp on the enemy with the most health. If used in an empty room or during the fight with Mom, it will stomp Isaac instead.
III - The Empress4 Pickup III - The Empress icon.png"May your rage bring power"Triggers the Whore of Babylon effect.
IV - The Emperor5 Pickup IV - The Emperor icon.png"Challenge me!"Teleports you into the Boss Room of a floor.
V - The Hierophant6 Pickup V - The Hierophant icon.png"Two prayers for the lost"Spawns 2 Soul Hearts.
VI - The Lovers7 Pickup VI - The Lovers icon.png"May you prosper and be in good health"Drops 2 full red hearts. If used in a Black Heart or Eternal Heart-containing Super Secret Room, it will spawn those types of hearts instead.
VII - The Chariot8 Pickup VII - The Chariot icon.png"May nothing stand before you"Grants the temporary invulnerability effect of My Little Unicorn.
VIII - Justice9 Pickup VIII - Justice icon.png"May your future become balanced"Spawns one of each consumable drop (a heart, a key, a bomb, and a coin).
IX - The Hermit10 Pickup IX - The Hermit icon.png"May you see what life has to offer"Teleports you to the shop. If there is no shop, this will act as a random teleport. If the shop has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).
X - Wheel of Fortune11 Pickup X - Wheel of Fortune icon.png"Spin the wheel of destiny"Spawns an arcade machine (Slot Machine or Fortune Teller).
XI - Strength12 Pickup XI - Strength icon.png"May your power bring rage"Upon use, increases all of Isaac's stats except tears and adds one (temporary) heart container for the current room.
XII - The Hanged Man13 Pickup XII - The Hanged Man icon.png"May you find enlightenment"Removes Isaac's body, allowing him to fly around similar to Transcendence.
XIII - Death14 Pickup XIII - Death icon.png"Lay waste to all that oppose you"Deals 40 damage to all enemies in the room.
XIV - Temperance15 Pickup XIV - Temperance icon.png"May you be pure in heart"Spawns a blood donation machine.
File:DLC Indicator.png Spawns a devil beggar in Greed Mode.
XV - The Devil16 Pickup XV - The Devil icon.png"Revel in the power of darkness"Increases your damage by 2 until you leave the room (same effect as the Book of Belial).
XVI - The Tower17 Pickup XVI - The Tower icon.png"Destruction brings creation"Spawns 6 troll bombs randomly around the room.
XVII - The Stars18 Pickup XVII - The Stars icon.png"May you find what you desire"Teleports the player to the Treasure Room. If there is no Treasure Room, this will act as a random teleport. Randomly chooses a Treasure Room on Curse of the Labyrinth. If the Treasure Room has not yet been accessed, this card will unlock the door without requiring a key (as long as the player exits through the main entrance).
XVIII - The Moon19 Pickup XVIII - The Moon icon.png"May you find all you have lost"Teleports the player to the Secret Room. This card will open one random wall once inside the Secret Room, so you can leave even if you don't have any bombs available.
XIX - The Sun20 Pickup XIX - The Sun icon.png"May the light heal and enlighten you"Restores full health, deals 100 damage to all enemies in the room, and reveals the map for the current floor, except the Super Secret Room.
XX - Judgement21 Pickup XX - Judgement icon.png"Judge lest ye be judged"Spawns a Beggar.
XXI - The World22 Pickup XXI - The World icon.png"Open your eyes and see"Reveals the entire floor, except for the Super Secret Room. Has no effect if under the effect of Curse of the Lost or Amnesia.

Playing Cards[edit | edit source]

When on the ground, these cards look like this: FaceCard.png

Name ID Icon Message Effect
2 of Clubs23 Pickup 2 of Clubs icon.png"Item multiplier"Doubles your bombs. If you have no bombs, gives you 2 instead.
2 of Diamonds24 Pickup 2 of Diamonds icon.png"Item multiplier"Doubles your coins. If you have no coins, gives you 2 instead.
2 of Spades25 Pickup 2 of Spades icon.png"Item multiplier"Doubles your keys. If you have no keys, gives you 2 instead.
2 of Hearts26 2 of Hearts Icon.png"Item multiplier"Doubles Isaac's current number of red hearts. Soul and Black hearts are unaffected. Doesn't add new heart containers, just fills empty ones.
Ace of Clubs File:Afterbirth† Indicator.png27 Pickup Ace of Clubs icon.png"Convert all"Turns all pickups and chests in the room into bombs.
Ace of Diamonds File:Afterbirth† Indicator.png28 Pickup Ace of Diamonds icon.png"Convert all"Turns all pickups and chests in the room into coins.
Ace of Spades File:Afterbirth† Indicator.png29 45x45px"Convert all"Turns all pickups and chests in the room into keys.
Ace of Hearts File:Afterbirth† Indicator.png30 Pickup Ace of Hearts icon.png"Convert all"Turns all pickups and chests in the room into random heart pickups.
Joker31 Pickup Joker icon.png"???"Teleports you to the Devil Room or Angel Room.

Special Cards[edit | edit source]

When on the ground, these cards look like this: FaceCard.png

Name ID Icon Message Effect

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Runes[edit | edit source]

Left Pointing Runes[edit | edit source]

When on the ground, these runes look like: Rune2.png

Rune ID Icon Message Unlocked method Effect
Hagalaz 32 Hagalaz Icon.png

Destruction

Rune of Hagalaz Beat challenge #1

Destroys all breakable objects in the room. Does not affect Key Blocks.

Jera 33 Jera Icon.png

Abundance

Rune of Jera Beat challenge #2

Clones all pickups and chests in a room (even shop pickups; the clones can then be picked up for free). Cloned chests will contain exactly the same type of items: if the original contains a pickup, so will the clone; the same is true for Collectibles. Cannot clone other Jera runes and trinkets.

Ehwaz 34 Ehwaz Icon.png

Passage

Rune of Ehwaz Beat challenge #3

Creates a trapdoor leading to the next floor. Has an estimated 1/12 (8%) chance to spawn a door to a Crawl Space instead.

Dagaz 35 Dagaz Icon.png

Purity

Rune of Dagaz Beat challenge #4

Removes any curses from the current floor and grants a soul heart. (This will not remove Curse of the Labyrinth.)

Right Pointing Runes[edit | edit source]

When on the ground, these runes look like: Rune1.png

Rune ID Icon Message Unlocked method Effect
Ansuz 36 Ansuz Icon.png

Vision

Rune of Ansuz Beat challenge #5

Reveals the whole map, including the Secret Room and the Super Secret Room.

Perthro 37 Perthro Icon.png

Change

Rune of Ansuz Beat challenge #5

Rerolls all pedestal items in the room. (This is the same effect as the D6.)

Berkano 38 Berkano Icon.png

Companionship

Rune of Berkano Beat challenge #20

Summons 3 friendly blue flies and 3 friendly blue spiders.

Algiz 39 Algiz Icon.png

Resistance

Rune of Algiz Beat challenge #8

Grants a shield which lasts for 30 seconds.

Blank Rune File:DLC Indicator.png 40 Pickup Blank Rune icon.png

???

Blank Rune Beat challenge #30 (The unlock is bugged and actually unlocks Kidney Stone in Afterbirth. Fixed in Afterbirth Plus.)

Grants a random rune effect. Has a 25% chance to spawn another Blank Rune upon use.

Other Runes[edit | edit source]

Rune ID Icon Message Unlocked method Effect
Black Rune File:Afterbirth† Indicator.png 41 Pickup Black Rune icon.png

Void

Black Rune Defeat Ultra Greedier as Apollyon

Deals 40 damage to all enemies in the room. Consumes all pickups in the room and turns them into blue flies and spiders. Consumes all pedestal items in the room and turns them into random stat upgrades.

Other[edit | edit source]

These are items other than cards and runes (and pills) that take up the consumable slot. When on the ground, each of these items are uniquely identifiable by their respective icon.

Name ID Icon Message Effect

{{:{{{1}}} | {{{1}}} | {{{2}}} }} {{:{{{1}}} | {{{1}}} | {{{2}}} }}

Notes[edit | edit source]

Unlockable Achievements[edit | edit source]

Trivia[edit | edit source]

  • In the expansion of the original game, Wrath of the Lamb, there was a positive pill effect called "Friends Till The End", which summoned 3 blue attack flies. This effect was improved, given to the rune Berkano in Rebirth, and added again in Afterbirth with the original effects.
  • The Suicide King card is a reference to the King of Hearts card, which is usually called that way because it depicts a king in a way that he appears to be sticking his sword into his head.
  • The Chaos Card is a reference to the Magic: The Gathering card "Chaos Orb", which also instantly destroys enemies that it touches.
  • The Get out of Jail Free card is a reference to a card with the same name that appears in the table game Monopoly.
  • The "A Card Against Humanity" card is a reference to the card game "Cards Against Humanity".

Bugs[edit | edit source]

Bug Bug! File:DLC Indicator.png Using the Joker card to enter a Devil Room / Angel Room in the Blue Womb will cause the music of the floor to continue playing instead of the normal Devil Room / Angel Room music.


SmallIsaac.png The Binding of Isaac: Lunatic Mod SmallIsaac.png

Boss Puck.png Bosses TarotCard.png Cards and Runes MainPageChallenges.png Challenges MainPageChapters.png Chapters Character Isaac appearance.png Characters Hammer Up Icon.png Items
Pumpkin Enemy.png Monsters MainPageObjects.png Objects BlueBlue.png Pills Guppy App.png Transformations Yellow Cap Icon.png Trinkets MainPageAchievements.png Unlockables

fr:Cartes et Runes